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Clinical and Administrative Pharmacy
Grants and Contracts
John M. Brooks, project director, has received funding from Harvard Medical School in the amount of $76,433, “Local Therapy of Breast Cancer in Community Populations.”
Barry Carter, project director, has received funding from the Health Sciences Foundation, Inc. in the amount of $3,969, “Support for Visiting Scholars from Japan.”
Barry Carter, project director, [co-investigators William Doucette, Karen Farris, Elizabeth Chrischilles, Michael Ernst, Arthur Hartz, George Bergus, Jessica Milchak, Paul James, David Katz, Christopher Goerdt, Janyce Stewqart, Karen Kluesner and Sheryl Eastin] has received funding from NIH in the amount of $671,651, “Collaborative Management of Hypertension.”
Barry Carter, project director, has received funding from the Iowa City Veterans Affairs Research Foundation in the amount of $5,072, “ICVARF-001.”
Barry Carter, co-investigator (Jessica Milchak, PI, $17,500) American College of Clinical Pharmacy, “Guideline Adherence and Blood Pressure Control in Elders.”
Barry Carter, project director, has received funding from the Japanese government in the amount of $4,760, “Support for Visiting Scholars from Japan.”
Elizabeth Chrischilles, co-investigator (Fredric Wolinsky, PI, $357,971) NIH, “Health and Health Services Use in the HRS/AHEAD.”
Elizabeth Chrischilles, co-investigator (Peter Thorne, PI, $1,000,000) NIH, “Environmental Health Sciences Research Center.”
Lawrence Fleckenstein, project director, has received funding from Medicines for Malaria Venture in the amount of $210,994, “Analysis of Pyronaridine and Artesuntate for Pynonaridine-Artesunate Development Project.”
Bradley Phillips, co-investigator (Francois Abboud, PI, $2,277,752) NIH, “Integrative Neurobiology of Cardiovascular Regulation.”
Publications
Liu Y, Doucette WR, Farris KB, Nayakankuppam D. “Drug Information Seeking Intention and Behavior after Exposure to Direct-to-Consumer Advertisement (DTCA) of Prescription Drugs,” Research in Social & Administrative Pharmacy, 2005;1:251-269.
Flach SD , Diekema DJ, Yankey JW, BootsMiller BJ, Vaughn TE, Ernst EJ, Ward MM, Doebbeling BN. Variation in the use of procedures to monitor antimicrobial resistance in US hospitals. Infection Control and Hospital Epidemiology 2005;26:31-38.
Ernst EJ, Ernst ME, Hoehns JD, Bergus GR. Women's quality of life is decreased by acute cystitis and antibiotic adverse effects associated with treatment. Health and Quality of Life Outcomes 2005; 3:45 (27 July 2005).
Ernst EJ, Raley G, Herwaldt LA, Diekema DJ. The Importance of Control Group Selection for Evaluating Antimicrobial Usage as a Risk Factor for Methicillin-resistant Staphylococcus aureus Bacteremia. Infection Control and Hospital Epidemiology 2005;52:634-637.
Ernst EJ. Chapter 1 Susceptibility Testing Methods of Antifungal Agents. In Antifungal Agents: Methods and Protocols.
Ernst EJ, Rodgers PD (eds.) Antifungal Agents: Methods and Protocols. The Humana Press Inc. 2005.
Farris KB, Phillips BB, Farley M, Schilling M, Ernst M, McDanel D, Steffensmeier J, Cavanaugh J. Predicting Medication Management Capacity among Older Adults. American Pharmacists Association Annual Meeting, April 2005.
Liu Y, Doucette WR, Farris KB, Nayakankuppam D, Drug information seeking intention and behavior after exposure to direct-to-consumer advertisement (DTCA) of prescription drugs. Research in Social & Administrative Pharmacy, 2005;1:251-269.
Farris KB, Fernandez-Llimos F, Benrimoj SI. Pharmaceutical care in community pharmacies: practice and research from around the world. Annals Pharmacother 2005;39:1539-41 (DOI 10.1345/aph.1G049).
Ficke DL, Farris KB. Use of the Trans-theoretical model in the medication use process. Annals Pharmacother 2005:39:1325-30. (DOI 10.1345/aph.1G122).
Simpson SH, Johnson JA, Farris KB, Lau TTY, Majumdar SR, Cave A, Tsuyuki RT, for the SCRIP Investigators. Physician perceptions of enhanced community pharmacist care in cholesterol management: a survey of physicians contacted during the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP). Can Pharm J 2005;138(4):33-39.
Feeny D, Farris KB, Côté I, Johnson JA, Tsuyuki RT, Eng. The construct validity of the RAND-12 and health utilities index mark 2 and mark 3 in High-risk primary care patients. J Clin Epidemiol 2005;58:138-41.
Naik H, Murry, DJ, Kirsch LE and Fleckenstein LL. Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma. J. Chromato. B. Biomedical Applications, 816:233-242, 2005.
Marty FM, Lowry CM, Rodriguez M, Milner DA, Pieciak WS, Sinha A, Fleckenstein LL, and Baden LR, Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin. Inf. Dis. 41:e5-8, 2005.
Goedken AM and Herman RA: Once-Daily Abacavir in Place of Twice-Daily Administration. Annals of Pharmacotherapy 39 (7/8):1302-8, 2005.
Kee VR. Bettor options: a review of pharmacotherapy for pathological gambling. World of Drug Information. 2005;16(1):1-7.
Bazaldua O, Ables AZ, Dickerson LM, Hansen L, Harris I, Hoehns J, Jackson E, Kraus C, Mayville H, Saseen J. Suggested guidelines for pharmacotherapy curricula in family medicine residency training: recommendations from the society of teachers of family medicine group on pharmacotherapy. Fam Med 2005;37(2):99-104.
Hellstein, J, Marek CL, "Bis-phossy jaw, Phossy Jaw and the 21st Century: Bisphosphonate Associated Complications of the Jaws" Accepted July 2004 by The Journal of Oral and Maxillofacial Surgery 2005:63(5):682-9.
Hatab AZ, McDanel DL, Ballas ZK. Peri-lesional GM-CSF (granulocyte monocyte-colony stimulating factor) therapy of a chronic leg ulcer in a CVID patient. [Letter] Journal of Allergy and Clinical Immunology 2005;116(2):460-2.
McDanel DL, Muller BA. The linkage between Churg-Strauss syndrome and leukotriene receptor antagonists: fact or fiction? [Review] Therapeutics and Clinical Risk Management 2005;1(2):125-40.
Ness J, Aronow WS, Newkirk EN, McDanel DL. Underutilization of Calcium and Vitamin D among Older Patients Seen in a Large General Internal Medicine Practice. American Journal of Therapeutics 2005;12(2):113-6.
Ness J, Aronow WS, Newkirk EN, McDanel DL. Prevalence of Symptomatic Peripheral Arterial Disease, Modifiable Risk Factors, and Appropriate Use of Drugs in the Treatment of Peripheral Arterial Disease in Older Persons Seen in a University General Medicine Clinic. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2005;60(2):255-7.
Ness J, Aronow WS, Newkirk EN, McDanel DL. Use of Hormone Replacement Therapy by Postmenopausal Women after the Publication of the Women’s Health Initiative Trial. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2005;60:460-2.
Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, Murry DJ, Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25;818(2):221-5. PMID: 15734162 [PubMed - indexed for MEDLINE].
Quinney SK, Sanghani SP, Davis WI, Hurley TD, Sun Z, Murry DJ, Bosron WF. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J Pharmacol Exp Ther. 2005 Jun;313(3):1011-6. Epub 2005 Feb 1. PMID: 15687373 [PubMed - indexed for MEDLINE].
Sweeney CJ, Mehrotra S, Sadaria MR, Kumar S, Shortle NH, Roman Y, Sheridan C, Campbell RA, Murry DJ, Badve S, Nakshatri H. The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer. Mol Cancer Ther. 2005 Jun;4(6):1004-12. PMID: 15956258 [PubMed - in process].
Phillips BB, Chronic Anticoagulation. in Schwinghammer TL.(editor): Pharmacotherapy: a patient-focused approach, 6 th edition. Appleton & Lange, Stamford, Connecticut 2005.
Phillips BB, Constipation, in Schwinghammer TL.(editor): Pharmacotherapy: a patient-focused approach, 6 th edition. Appleton & Lange, Stamford, Connecticut 2005.
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Medicinal and Natural Products Chemistry
Grants and Contracts
Tom Prisinzano has been selected to receive a D. John Faulkner Travel Grant for $1000, enabling him to attend the 46th Annual Meeting of the American Society of Pharmacognosy in Corvallis, Oregon. He was the first recipient of this prestigious award! This award was initiated as a tribute to D. John Faulkner as a mentor and the committee hopes it allows you to enjoy a very interesting, stimulating and diverse meeting on natural products research. He has also been awarded an INRC Travel Award of $900 to attend the INRC Meeting in Annapolis, Maryland.
Zhendong Jin, project director, has received funding from the University of Texas, MD Anderson Cancer Center in the amount of $50,000, “Antitumor Activity and Mechanism of OSW-1 in Pancreatic Cancer.”
Publications
Carbone DL, Doorn JA, Kiebler Z, and Petersen DR. (2005) Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. Chem. Res. Toxicol. [in press]
Carbone DL., Doorn JA, Kiebler Z, Ickes BR, and Petersen DR. (2005) Modification of Hsp90 by lipid peroxidation products in a rat model of chronic alcoholic liver disease. J. Pharmacol. Exp. Ther. [in press, published online 6/10/2005].
Apak TI and Duffel MW. 2004. Interactions of the stereoisomers of a -hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa. Drug Metabolism and Disposition, 32: 1501-1508.
Sharma V and Duffel MW. 2005. A comparative molecular field analysis (CoMFA) based approach to prediction of sulfotransferase catalytic specificity. Methods in Enzymology, 400: In Press.
Synthetic Studies toward the Construction of the cis-Decalin Portion of Superstolides A and B. Application of a Sequential Double Michael Reaction and an Anionic Oxy-Cope Rearrangement, Hua Z, Yu W, Su M, Jin Z. Org. Lett. 2005, 7, 1939.
Wei P, Kerns RJ, Chemoselective Deprotection and Functional Group Interconversion of trans-Fused 2N,3O-Oxazolidinones of N-Acetyl- D -Glucosamine. Tetrahedron Lett. 2005 (in press).
Wei P, Kerns RJ, Factors Affecting Stereocontrol during Glycosidation of 2,3-Oxazolidinone Protected 1-Tolylthio-N-acetyl-D-glucosamine. J. Org. Chem. 2005, 70, 4195-4198.
Malik M, Lu T, Zhao X, Singh A. Hattan CM, Domagala J, KernsRJ, Drlica K. Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol. Antimicrobial Agents Chemother. 2005, 49, 2008-2014.
Synthesis of (+)-Modafinil. Olivo HF , Osorio-Lozada A, and Peeples TL. Tetrahedron: Asymmetry 2005, in press.
Stereoselective Addition of the Titanium Enolate of N-Acetyl (4S)-Isopropyl-1,3-thiazolidione-2-thione to 5-Membered N-Acyl Iminium Ions. Barragán E, Olivo HF , Romero-Ortega M, and Sarduy S. J. Org. Chem. 2005, 70, 4214-4217.
Sulima A, Prisinzano TE, Jacobson AE, Rice KC, Spande T, Whitaker N, Deschamps J R, Hochberg, ZA. Concise Method for the Preparation of Deuterium-labeled Cortisone: Synthesis of [6,7- 2H]Cortisone. Steroids 2005, in press.
Schmidt MS, Prisinzano TE, Tidgewell K, Harding WW, Butelman ER, Murry D J. Determination of Salvinorin A in Body Fluids by High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization. J. Chromatogr. BAnalyt. Technol. Biomed. Life Sci . 2005, 818, 221-225.
Harding WW, Tidgewell,K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Neoclerodane Diterpenes as a Novel Scaffold for m Opioid Receptor Ligands. J. Med. Chem.2005, 48, 4765-4771.
Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE. Enantioselective Synthesis of (R,R)- and (S,S)-2-[(3-Chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine Tetrahedron – Asymmetr.2005, 16, 2249-2256.
Harding, WW, Tidgewell K, Schmidt M, Shah K, Dersch C M, Synder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicin A and B, New Neoclerodane Diterpenes from Salvia divinorum. Org. Lett. 2005, 7, 3017-3020.
Oyewumi MO and Rice KG. “DNA Nanoparticle Gene Delivery Systems” in Nanotechnology for Drug Delivery, Marcel Dekker, Inc., Eds, . Gupta RB and Kompella UB. (2005) in press.
Huang YC, Rice KG, Mooney DJ.“Long-term In Vivo Gene Expression Via Delivery of PEI-DNA Condensates from Porous Polymer Scaffolds” Human Gene Therapy (2005) 16, 609-617.
Huang YC, Rice KG, Mooney DJ. “Bone Regeneration in a Rat Cranial Defect with Delivery of PEI-Condensed Plasmid DNA Encoding for Bone Morphogenetic Protein-4” Gene Therapy (2005) 12, 418-426.
Kim JS, Chen C and Rice KG. “The Proteasome Metabolizes Peptide-Mediated Non-Viral Gene Delivery Systems” Gene Therapy, June 30, 2005; doi:10.1038/sj.gt.3302579.
Huang, YC, Kaigler D, Rice KG, Krebsbach PH, Mooney DJ. “Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration.” J. Bone and Mineral Research (2005) May;20(5):848-57.
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Pharmaceutics
Grants and Contracts
Craig Svensson, project director, has received funding from Novartis Consumer Health, Inc. in the amount of $9,900, “Novartis Consumer Health Fellowship.”
Craig Svensson, project director, has received funding from Novartis Pharmaceuticals Corporation in the amount of $13,500, “Student Internship with Novartis Pharmaceutics Corporation.”
Craig Svensson, project director, has received funding from Novartis Pharmaceuticals Corporation in the amount of $33,600, “Student Internship with Novartis Pharmaceutics Corporation.”
Publications
Donovan MD, Sex and Racial Differences in Pharmacologic Response: Effect of Route of Administration and Drug Delivery System on Pharmacokinetics. J Womens Health 14(1), 30-37, 2005.
Kandimalla K and Donovan MD, Carrier Mediated Transport of Chlorpheniramine and Chlorcyclizine across Bovine Olfactory Mucosa: Implications on Nose-to-Brain Transport. J Pharm Sci 94, 613-624, 2005.
Sinn PL, McCray PB, Donovan MD, Shah AJ, Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors. Am J Resp Cell Mol Biol 32, 404-410, 2005.
Chemuturi NV, Hayden P, Klausner M, and Donovan MD, Comparison of human tracheal/bronchial epithelial cell cultures (EpiAirway) and bovine nasal respiratory explants for nasal drug transport studies. J Pharm Sci 94, 1976-1985, 2005.
Kandimalla K and Donovan MD, Localization and Differential Activity of P-glycoprotein in the Bovine Olfactory and Nasal Respiratory Mucosae. Pharm Res 22, 1121-1128, 2005.
Liu IKM, Turner JW, VanLeeuwen EMG, Flanagan DR , Hedrick JL, Murata K, Lane VM and Morales-Levy MP, "Persistence of Anti-Zona Pellucidae Antibodies Following a Single Innoculation of Porcine Zona Pellucidae in the Domestic Equine," Reproduction, 129, 181-190 (2005).
Khawam A and Flanagan DR, "Role of Isoconversional Methods in Varying Activation Energies of Solid-State Kinetics" I. Isothermal Kinetic Studies, Thermochim. Acta, 429, 93-102 (2005).
Khawam A and Flanagan DR, "Complementary Use of Model-Free and Modelistic Methods in the Analysis of Solid-State Kinetics", J. Phys. Chem. A, 109, 10073-10080 (2005).
Joshi, AB and Kirsch LE, "Studies on the Mechanism of Aspartic Acid Cleavage and Deamidation in the Acidic Degradation of Glucagon", Journal of Pharmaceutical Sciences , 94(9): 1912-1927, 2005.
Muangsiri W, Kearney WR, Teesch LM, Kirsch LE, "Studies on the Reactions between Daptomycin and Glyceraldehyde", International Journal of Pharmaceutics , 289(1-2): 133-150, 2005.
Naik H, Murry DJ, Kirsch LE, Fleckenstein LL, "Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and its metabolite dihydroartemisinin in human plasma", Journal of Chromatography B, 816(1-2): 233-242, 2005.
Yang D and Kumar VJ, Study of the Influence of Reaction Conditions on Degree of Substitution, Intrinsic iscosity, and Yield of Oxidized Cellulose Acetates by Experimental Factorial Design, J. Appl. Polym. Sci., 96, 696 (2005).
Salem AK, Hung CF, Kim TW, Wu TC, Searson PC, Leong KW. Multi-Component Nanorods for Vaccination Applications. Nanotechnology. 4 (16): 484-487 APR 2005.
Hultgren A, Tanase M, Felton EJ, Bhadriraju K, Salem AK, Chen CS, Reich DS. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515 APR 2005.
Roychowdhury S, Vyas PM, Reilly TP, Gaspari AA, Svensson CK. Characterization of the formation and localization of sulfamethoxazole- and dapsone-associated drug-protein adducts in human epidermal keratinocytes. Journal of Pharmacology and Experimental Therapeutics 314:43-52, 2005.
Vyas PM, Roychowdhury S, Woster PM, Svensson CK. Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes. Biochemical Pharmacology 70:275-286, 2005.
Kamp V, Kirk A, Qiang D, Aburub A, and Wurster DE, “Modified Langmuir-like Model for Modeling the Adsorption from Aqueous Solutions by Activated Carbons,” Langmuir, 21, 217-224 (2005).
Wurster DE and Bandopadhyay R, “The Use of Isoperibol Calorimetry for the Study of Age-related Changes in Glucose Uptake by Erythrocytes,” Journal of Thermal Analysis and Calorimetry, 79, 737-740 (2005).
Li LC,, Zhu L, Song J, Deng JS, Bandopadhyay R and Wurster DE, “Effect of Solid State Transition on the Physical Stability of Suspensions Containing Bupivacaine Lipid Microparticles,” Pharmaceutical Development and Technology, 10(2), 309-318 (2005).
Dogan UA, Dogan M, Chan D and Wurster DE, "Bassanite from Salvadora Persica: a New Evaporitic Biomineral," Journal of Carbonates and Evaporites, 20(1), 2-7 (2005).
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