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 Aliasger K. Salem, Ph.D.,
Assistant Professor,
Division of Pharmaceutics
Contact Information:
Division of Pharmaceutics
College of Pharmacy, University of Iowa
115 S. Grand Avenue, S228 PHAR
Iowa City, IA 52242
Phone: 319 335-8810
FAX: 319 335-9349
aliasger-salem@uiowa.edu
Salem Group Homepage
Education
1998 BSc (1st Class Hons Applied Chemistry); Aston University, U.K.
2002 Ph.D. (Pharmaceutical Sciences); University of Nottingham, U.K.
2002-2004 Postdoctoral Fellowship (Medicine); The Johns Hopkins University
Professional Experience
2004-present Assistant Professor, College of Pharmacy, University of Iowa
2002-2004 Postdoctoral Fellow, Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University
2001-2002 Scientific Consultant, Regentec Ltd, Nottingham, U.K.
1998-2001 Scientist, Pharmaceutical Profiles, Nottingham, U.K.
Research Interests
Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses. Dr Salem's laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions. The group is currently exploring the synergistic application of polymer particle technology, CpG oligonucleotides, adenoviruses and heat shock protein therapy for generating sustained stronger immune responses against tumors.
Recent Publications
R. Goforth, Salem AK, X. Zhu, S. Miles, X.Q. Zhang, J. Lee, A.D. Sandler. Immune Stimulatory Antigen Loaded Particles Combined with Depletion of Regulatory T-cells Induce Potent Tumor Specific Immunity in a Mouse Model of Melanoma. Cancer Immunology, Immunotherapy 2008
J. Intra, Salem AK. Characterization of the Transgene Expression Generated by Branched and Linear Polyethylenimine (PEI)-Plasmid DNA Nanoparticles In Vitro and After Intraperitoneal Injection In Vivo. Journal of Controlled Release. 2008
Pearce ME, Mai HQ, Lee N, Larsen SC, Salem AK. Silicalite nanoparticles that promote transgene expression. Nanotechnology 2008
J. Intra, J.M Glasgow, H. Q. Mai, Salem AK. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release 2008
J.D. Clapper, M.E. Pearce, C.A. Guymon, Salem AK. Biotinylated Biodegradable Nanotemplated Hydrogel Networks for Cell Interactive Applications. Biomacromolecules 2008
Y. Krishnamachari, M.E. Pearce, Salem AK. Self-assembly of cell-microparticle hybrids. Advanced Materials. 2008
X.Q. Zhang, J. Intra, Salem AK. Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation. 2008 1-13
Salem AK. Frontiers in Drug Design and Discovery. Volume 3. Journal of Medicinal Chemistry. 2008
Y. Krishnamachari, Salem AK. Nano-Bio Polymers and Composites. Invited chapter in "Nano-and Biocomposites". Taylor & Francis/CRC Press. Edited by Lau and Hussain. 2008
J. Glasgow, Salem AK. Stem Cells and Cancer. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008
M.E. Pearce, Salem AK. Stem Cell Research in Iowa. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008
X.Q. Zhang, J. Intra, Salem AK. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for non-viral gene delivery. Bioconjugate Chemistry. 2007 Nov-Dec;18(6):2068-76
A.O. Abbas, M.D. Donovan, Salem AK. Formulating PLGA particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences. 2007 DOI: 10.1002/jps.21215
M.E. Pearce, J.B. Melanko, Salem AK. Biomedical applications of multifunctional nanorods. Pharmaceutical Research. 2007 Dec; 24(12):2335-52
X.Q. Zhang, C.E. Dahle, G.J. Weiner and Salem AK. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. Journal of Pharmaceutical
Sciences. 2007 Dec;96(12):3283-92
X.Q. Zhang, C.E. Dahle, N.K. Baman, N. Rich, G.J. Weiner and Salem AK. Potent antigen-specific immune responses stimulated by co-delivery of CpG ODN and antigens in degradable microparticles. Journal of Immunotherapy, 30 (5): 469-478 July/August 2007
Salem AK, M. Behlke. siRNA delivery vehicles. Invited Chapter in the Book entitled "RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development". John Wiley & Sons Inc. 2007 Edited by Teresa N. Faria, Siew Peng Ho, and Oliver Steinbach.
J.B. Melanko, M.E. Pearce, Salem AK. Nanotubes/nanorods/nanofibers/fullerenes for nanoscale drug delivery. Invited Chapter in the Book entitled "Nanotechnology in Drug Delivery". Springer Science/American Association for Pharmaceutical Scientists (AAPS) 2007. Edited by Melgardt M. de Villiers, and Glen S. Kwon.
Salem AK, M.K. Salem, H.K. Salem, S. Tapya. New technologies and therapies for cancer. Invited review for the "Encyclopedia of Cancer and Society". Sage Publications 2007 . Edited by J. Geoffrey Golson and Graham A. Colditz.
J. Sinclair, Salem AK. Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking. Biomaterials. 27 2090-2094 MAR 2006
N.K Baman, G.B. Schneider, T.L. Terry, R. Zaharias, Salem AK. Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. International Journal of Nanomedicine, 1 (2): APR 2006
Salem AK. Frontiers in Drug Design and Discovery. Volume 2. Journal of Medicinal Chemistry. 2006 Dec 14;49(25):7555-6.
Salem AK, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, K.W. Leong. Multi-component nanorods for vaccination applications. Nanotechnology. 4 (16): 484-487 APR 2005
A. Hultgren, M. Tanase, E.J. Felton, K. Bhadriraju, Salem AK, C.S. Chen, D.H. Reich. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515 APR 2005
Salem AK and K.W. Leong. Polymer scaffolds for tissue engineering and gene delivery. Invited Chapter in the Book entitled "Scaffolding in Tissue Engineering". CRC Press 2005 Edited by: Jennifer Elisseeff and Peter X. Ma
Salem AK, M. Chen, J. Hayden, K.W. Leong, and P.C. Searson. Directed assembly of multi-segment Au/Pt/Au nanowires. Nanoletters. 4 (6): 1163-1165 JUN 2004
Salem AK, J. Chao, K.W. Leong, and P.C. Searson. Receptor mediated self-assembly of multi-component magnetic nanowires. Advanced Materials. 16 (3): 268+ FEB 3 2004
Salem AK, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671
H.S. Sakhalkar, M.K. Dalal, Salem AK, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proceedings of the National Academy of Sciences. 100 (26): 15895-15900 DEC 23 2003
Salem AK, F.R.A.J. Rose, R. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous polymer and cell composites that self assemble in situ. Advanced Materials. 15 (3): 210-213 FEB 5 2003
Salem AK, R. Stevens, R.G. Pearson, M.C. Davies, S.J.B. Tendler and K.M. Shakesheff. Interactions of 3T3 fibroblasts and endothelial with defined pore features. Journal of Biomedical Materials Research. 61 (2) 212-217 Aug 2002
Salem AK, S.M. Cannizzaro, M.C. Davies, S.J.B. Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Synthesis and characterisation of a degradable biotinylated polylactic acid-polyethylene glycol copolymer. Biomacromolecules. Sum 2001, 2, 575-580
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