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Kevin G. Rice, Ph.D.,
Professor and Division Head of Medicinal & Natural Products Chemistry,
Professor, Division of Pharmaceutics
Contact Information:
Division of Medicinal & Natural Products Chemistry, Rm 300
College of Pharmacy
The Dale E. Wurster Center for Pharmaceutical Technology
The University of Iowa
Iowa City, IA 52242
Phone: (319) 335-9903; Fax: (319) 335-8766
Email: kevin-rice@uiowa.edu
Alternate webpage: http://www.pharmacy.uiowa.edu/mnpcphar/Pages/rice.htm
Education
1987-91 Postdoctoral Fellow; Department of Biology, The Johns Hopkins University
1987 Ph.D. (Medicinal & Natural Products Chemistry); The University of Iowa
1983 B.S. (Chemistry & Biology); Marycrest College
Professional Experience
| 2001-present, Professor and Division Head, Medicinal & Natural Products Chemistry, Professor of Pharmaceutics, College of Pharmacy, The University of Iowa |
1997-2001, Associate Professor of Medicinal Chemistry and Pharmaceutics, College of Pharmacy,
The University of Michigan |
1995-1997, Assistant Professor of Medicinal Chemistry and Pharmaceutics, College of Pharmacy,
The University of Michigan |
1991-1994, Assistant Professor of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,
The Ohio State University |
| 1987-1991. Postdoctoral
Fellow, Department of Biology, The Johns Hopkins University, Baltimore,
Maryland |
Research Interests
Dr. Rice's research interests are in the synthesis and testing of carrier systems for targeted gene delivery. His studies involve peptide, carbohydrate and bioconjugate synthesis, gene formulation, in vitro and vivo testing of gene delivery systems.
Recent Publications
Rettig GR, Rice KG, "Non-viral gene delivery: from the needle to the nucleus", Expert Opin Biol Ther. 2007 Jun;7(6):799-808.
Chen CP, Kim JS, Liu D, Rettig GR, McAnuff M, Martin ME and Rice KG, "Synthesis of PEGlyated Glycoproteins and their Utility in Gene Delivery", Bioconj. Chem. 2007 Mar-Apr;18(2):371-8.
McAnuff M, Rettig GR and Rice KG, "Potency of siRNA Versus shRNA Mediated Knockdown in Vivo", J. Pharm. Sci. 2007 May 22;96(11):2922-2930.
Martin ME and Rice KG, "Peptide Guided Gene Delivery" AAPS J. 2007 Feb 9;9(1):E18-29.
Rettig GR, McAnuff M, Liu D, Kim J and Rice KG, "Quantitative Bioluminescence Imaging of Transgene Expression In Vivo" Anal. Biochem. (2006) 335, 90-94.
Chen C, Kim J, Steenblock E, Liu D and Rice KG, "Gene Transfer with Polymelittin Peptides" Bioconj. Chem., (2006) 17, 1057-1062.
Oyewumi MO and Rice KG, “DNA Nanoparticle Gene Delivery Systems” in Nanotechnology for Drug Delivery, Marcel Dekker, Inc., Eds, R.B. Gupta and U.B. Kompella. (2006) Ch. 12, pp. 361-379
Huang YC, Rice KG and Mooney DJ, “Long-term In Vivo Gene Expression Via Delivery of PEI-DNA Condensates from Porous Polymer Scaffolds” Human Gene Therapy (2005) 16, 609-617.
Huang YC, Rice KG and Mooney DJ, “Bone Regeneration in a Rat Cranial Defect with Delivery of PEI-Condensed Plasmid DNA Encoding for Bone Morphogenetic Protein-4” Gene Therapy (2005) 12, 418-426.
Kim J, Chen CP and Rice KG, “The Proteasome Metabolizes Peptide-Mediated Non-Viral Gene Delivery Systems” [Journal Article] Gene Therapy, 12(21):1581-90, 2005 Nov. UI 16034460.
Huang YC, Kaigler D, Rice KG, Krebsbach PH, Mooney DJ, “Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration.” J. Bone and Mineral Research (2005) May;20(5):848-57.
Elhalabi J and Rice KG, “Synthesis of Uridine 5’-[2-S-pyridyl-3-thio-a-D-galactopyranosyl diphosphate] Precursor of UDP-Thiogal Sugar Nucleotide Donor Substrate for beta-1,4 Galactosyltransferase” Nucleosides, Nucleotides & Nucleic Acids 23(1-2):195-205, 2004.
Thanawiroon C, Rice KG, Toida T, and Linhardt RJ, “Liquid Chromatography/Mass Spectrometry Sequencing Approach for Highly Sulfated Heparin-derive Oligosaccharides” J. Biol. Chem. (2004) 279, 2608-2615.
Chen C, Park Y and Rice KG, “An Improved Large-Scale Synthesis of PEG-Peptides for Gene Delivery” J. Peptide Research (2004) 64, 237-243.
Rice KG, Kim JS and Liu D, “Glycopolymers Tools for Studying Targeted Non-viral Gene Delivery” in Polymeric Gene Delivery, (Mansoor M. Amiji Ed.) CRC Press (2004) pgs 509-521.
Kwok KY, Park Y, Yang Y, McKenzie DL, Liu Y and Rice KG, “In Vivo Gene Transfer using Sulfhydryl Crosslinked PEG-peptide/Glycopeptide DNA Co- Condensates” J. Pharm. Sci. (2003) 92, 1174-1185.
Huang YC, Connell M, Park Y, Mooney D and Rice KG, "Fabrication and In Vitro Testing of a Polymeric Delivery System for Condensed DNA "J. Biomed. Mater. Res. (2003) 67, 1384-92.
Rice KG, Thomas VH and Yang Y, "Probing the Binding Specificity of C-Type Lectins In Vivo", Meth. Enzymol. (2003) 363, 90-104.
Park Y, Kwok KY, Boukarim C, and Rice KG, “Synthesis of Sulfhydryl Crosslinking Poly (ethylene glycol) Peptides and Glycopeptides as Carriers for Gene Delivery.” Bioconj. Chem. (2002) 13, 232-239.
Elhalabi J and Rice KG, “Thiosugar Nucleotide Analogs; Synthesis of Uridine 5’-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactophyranosyl diphosphate)” Carbohydr. Res. 337(21-23):1935-1940, 2002 Nov 19.
Rice KG, "Preparative Purification and Utilization of Tyrosinamide N-Glycan Libraries" in Carbohydrate Analysis by Modern Chromatography and Electrophoresis, Journal of Chromatography Library, Elsevier, Amsterdam, The Netherlands, (2002) Vol 66, pp 535-570.
Kwok KY, Yang YS and Rice KG, “Evolution of Cross-linked Non-viral Gene Delivery Systems” Current Opinion in Molecular Therapeutics (2001) 3, 142-146.
Yang YS, Man S, Park Y, Liu Y and Rice KG, "Cross-linked Low Molecular Weight Glycopeptide Mediated Gene Delivery: Relationship Between DNA Metabolic Stability and the Level of Transient Gene Expression In Vivo" J. Pharm. Sci. (2001) 90, 2010-2022.
Elhalabi J and Rice KG, “Synthesis of thiosugar nucleotide analogues; synthesis of uridine 5`-(2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-alpha-D-galactopyranosyl diphosphate)” Carbohydr. Res. (2001) 335, 159-165.
Rice KG, “Application of Fluorescence Resonance Energy Transfer to Analyze Carbohydrates” Anal. Biochem. (2001) 297, 117-122.
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