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Lee E. Kirsch, Ph.D.,
Associate Professor,
Division of Pharmaceutics
Contact Information:
Division of Pharmaceutics, S221
College of Pharmacy
The Dale E. Wurster Center for Pharmaceutical Technology
The University of Iowa
Iowa City, IA 52242
Phone: (319) 335-8824; Fax: (319) 335-9349
Email: lee-kirsch@uiowa.edu
Education
1975 B.S. (Pharmacy), Purdue University
1982 Ph.D. (Pharmaceutics), The Ohio State University
Professional Experience
1994-DATE Associate Professor; Division of Pharmaceutics, College of Pharmacy, The University of Iowa
1992-1994 Senior Research Scientist; Lilly Research Laboratories
1987-1992 Research Scientist; Lilly Research Laboratories
1982-1987 Senior Pharmaceutical Chemist; Lilly Research Laboratories
Research Interests
Dr. Kirsch's research interests include macromolecular peptide prodrugs for targeted drug delivery, the kinetics and mechanisms of the chemical instability of drugs, the kinetics and mechanisms of the physical instability of dispersed and colloidal systems, and pharmaceutical package integrity technologies.
Recent Publications
Joshi, A.B. and Kirsch LE, "Studies on the Mechanism of Aspartic Acid Cleavage and Deamidation in the Acidic Degradation of Glucagon", Journal of Pharmaceutical Sciences, 94(9): 1912-1927, 2005.
Walaisiri Muangsiri, William R. Kearney, Lynn M. Teesch, Kirsch LE, "Studies on the Reactions between Daptomycin and Glyceraldehyde", International Journal of Pharmaceutics, 289(1-2):133-150, 2005.
Himanshu Naik; Murry, Daryl J; Kirsch LE, Fleckenstein, L., "Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artsunate and its metabolite dihydroartemisinin in human plasma", Journal of Chromatography B, 816(1-2): 233-242, 2005
Joshi, Anjali B.; Kirsch LE, The estimation of glutaminyl deamidation and aspartyl cleavage rates in glucagon. International Journal of Pharmaceutics (2004), 273(1-2), 213-219.
Xiaoguang Zhang and Kirsch LE, “Correlation of the Thermal Stability of Phospholipid-based Emulsions and Microviscosity Measurements as Determined by Fluorescence Polarization”, Pharmaceutical Development and Technology, 9(2): 219-227, 2004.
Joshi, A. B. and Kirsch LE, "The estimation of glutaminyl deamidation and aspartyl cleavage rates in glucagon", International Journal of Pharmaceutics, in press, 2004.
Xiaoguang Zhang and Kirsch LE, "The Physical Stability of Thermally-stressed Phospholipid-based Emulsions Containing Methyl, Propyl and Heptyl Parabens as Model Drugs", International Journal of Pharmaceutics, 265(1-2), 133-140, 2003.
Joshi, A. B. and Kirsch LE, "The Relative Rates of Asparaginyl and Glutaminyl Deamidation in Glucagon Fragment 22-29 under Acidic Conditions", Journal of Pharmaceutical Science, 91(11), 2332-2345, 2002.
Kirsch LE, "Beyond bioterrorism" PDA Journal of Pharmaceutical Science and Technology, 56(3), 113-114, 2002.
Walaisiri Muangsiri and Kirsch LE, "The Kinetics of Daptomycin Degradation in Alkaline Solutions", Journal of Pharmaceutical Science, 90(8), 1066-1075, 2001.
Kirsch LE "Pharmaceutical Container/Closure Integrity VI: Correlations Between Liquid Tracer Methods and Microbial Ingress." PDA Journal of Pharmaceutical Science and Technology, PDA Journal of Pharmaceutical Science and Technology, 54(4):305, 2000.
Kirsch LE, Lida Nguyen, Craig S. Moeckly, Ronald Gerth "Pharmaceutical Container/Closure Integrity II: The Relationship Between Microbial Ingress and Helium Leak Rates in Rubber-stoppered Glass Vials", PDA Journal of Pharmaceutical Science and Technology, 51(5):195, 1997.
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