| Professional
Experience |
| University of
Kansas, Faculty, Department of Medicinal Chemistry, 1962-1984 |
| University of
Kansas, Associate Dean, College of Pharmacy, 1983-1984 |
|
University
of Iowa, College of Pharmacy, Dean, 1984-1991
|
| University of
Iowa, College of Pharmacy, Professor, 1991- |
| Research |
|
Professor Wiley
has published about 45 papers dealing with synthesis of potential
drugs and chemical mechanisms in toxicology. His current research
interests include design of inhibitors of enzymes of cardiovascular
significance, particularly endothelin converting enzyme, and the
role of platelet activating factor and its analogues in blood pressure
control and blood platelet activation.
|
|
Representative Publications
|
|
R.A. Wiley and D.H. Rich, "Protein Processing Enzymes," chapter
in Peptidomimetics, D.H. Rich and H. Kessler, eds., Weinheim, VCH,
1995: in press.
|
| R.A. Wiley and D.H. Rich, "Peptidomimetics Derived from
Natural Products," Med. Res. Revs., 13, 1993: 327-384. |
|
P. Zenk, R. Brinkman, L. Gammal, V. Penka, J. Bresnahan, R. Wiley,
and G. Traiger, "Toxicity of Alkyldihydrofurans to Metabolically
Active Organs in the Mouse," Toxicology, 61, 1990: 47-57.
|
|
Michael H. Marx, Robert A. Wiley, D.G. Satchell, and M. Helen Maguire,
"Darmstoff Analogues.3. Actions of Choline Esters of Acetal Phosphatidic
Acids on Visceral Smooth Muscle," J. Med. Chem., 32, 1989: 1319-1322.
|
| N. Narashiman, Paul E. Weller, John A. Buben, Robert
A. Wiley, and Robert P. Hanzlik, "Microsomal Metabolism and Covalent
Binding of [3H/14C]-bromobenzene. Evidence for Quinones as Reactive
Metabolites," Xenobiotica, 18(5), 1988: 491-499. |
| M.H. Marx, and R.A. Wiley, "Synthesis of Platelet Activating
Actor (PAF) via a Cyclic Tin Intermediate," Tetrahedron Lett. 1985:
1379. |
| B.S. Ross, and R.A. Wiley, "Tetracyclic Pyridazines
as Potential Psychopharmacological Agents," J. Med. Chem., 28, 1985:
870. |
|
