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MIKI 2008
David L. Roman
Division of Medicinal and Natural Products Chemistry
College of Pharmacy, University of Iowa
115 S. Grand Avenue - Rm. S327
Iowa City, Iowa 52242

Roman Lab Website: http://www.romanlab.net
tel: 319-335-6920
fax: 319-335-8766
email: david-roman@uiowa.edu

Roman
Education
  • B.S., Chemistry & Biological Sciences, Quincy University, Quincy, IL, 1998

  • Ph.D., Medicinal Chemistry & Molecular Pharmacology, Purdue University School of Pharmacy, 2004
Professional Experience

Postdoctoral Fellow, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 2004-2008

Assistant Professor of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, 2008-
 
Awards

ASPET Board of Publications Trustees Travel Award, 2007

ASPET Molecular Pharmacology Young Investigator Award Finalist, 2005

University of Michigan Biomedical Research Council Fellowship, 2004
ASPET Graduate Student Travel Award for Experimental Biology, 2003
Quincy University Senior Chemistry Award, 1998
ACS Mark Twain Section, Outstanding Achievement Award , 1998
Elected to Kappa Gamma Pi National Honor Society, 1997
Phi Eta Sigma National Honor Society, 1995
Quincy University Organic Chemistry Award, 1995
Quincy University Scholarship, 1994-1998
Moorman Manufacturing Science Scholarship, 1995-1998
 
Research
Dr. Roman's research interests are High Throughput Screening, the development of Regulators of G Protein Signaling (RGS) Proteins as drug targets, and the use of Flow Cytometry for studying protein-protein interactions.
 
Representative Publications

Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT.
Microfabricated channel array electrophoresis for characterization and screening
of enzymes using RGS-G protein interactions as a model system.
Anal Chem. 2008 Jul 1;80(13):5225-31.

Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL,
Neubig RR, Mosberg HI.  Novel Peptide Ligands of RGS4 from a Focused One-Bead, OnCompound Library. Chem Biol Drug Des. 2008 Jul 14.

Bernsteel DJ, Roman DL and Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Submitted to Analytical Biochemistry

Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR & Neubig RR. (2007). Identification of small molecule inhibitors of Regulator of G-protein Signaling 4 (RGS4) using a high throughput flow cytometry protein interaction assay (FCPIA). Mol Pharmacol. 71,1 169-175

Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI & Neubig RR. (2006). Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design 67, 266-274.

Roman DL, Saldana SN, Nichols DE, Carroll FI & Barker EL. (2004). Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics 308, 679-687.

College of Pharmacy
115 S. Grand Avenue Iowa City,
Iowa 52240
(319) 335-8794

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