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Zhendong Jin

tel: 319-353-5359
fax:319-335-8766
email: zhendong-jin@uiowa.edu

 

Education
  • B.S., Chemistry, East China Normal University, 1988

  • M.S., Chemistry, SUNY College at Buffalo, 1990

  • Ph.D. Chemistry, Purdue University (under the guidance of Prof. Philip L. Fuchs) 1995

    Jin Research Presentation

Professional Experience
NIH Postdoctoral Fellow
The Scripps Research Institute, (w/ Prof. K. C. Nicolaou) Feb. 1996-July 1997
University of Iowa, College of Pharmacy, Assistant Professor, 1997-2003
University of Iowa, College of Pharmacy, Associate Professor, 2003-
Research

The main emphasis of my research is the total synthesis of various biologically active natural products and structural analogues, the discovery and development of new synthetic methods with particular interest in asymmetric reactions, and synthesis of small libraries with the aim of anticancer drug discovery.

Representative Publications

From The University of Iowa

An Improved Procedure for the Separation of (+) or (-)-Isopinocampheol, the Major Side Product of Brown's Asymmetric Crotylboranate Reactions, Hua, Z.; Jin, Z. Tetrahedron Lett. 2007, 48, 7695.


Ethoxyacetylene. Lou, C.; Jin, Z. Encyclopaedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd. 2005.

OSW-1: A Natural Compound with Potent Anticancer Activity and Novel Mechanism of Action, Zhou, Y.; Garcia-Prieto, C.; Carney, D.; Xu, R.; Pelicano, H.; Kang, Y.; Yu, W. Lou, C.; Kondo, S.; Liu, J.; Harris, D.; Estrov, Z.; Keating, M. J.; Jin, Z.; Huang, P. Journal of the National Cancer Institute, 2005, 97, 1781.

Synthetic Studies toward the Construction of the cis-Decalin Portion of Superstolides A and B. Application of a Sequential Double Michael Reaction and an Anionic Oxy-Cope Rearrangement, Hua, Z; Yu, W.; Su, M.; Jin, Z. Org. Lett. 2005, 7, 1939.

Heck Reaction with an Acyl Synthon: New Coupling Reaction between α-Halo Vinyl Ether and Alkene, Gao, X.; Yu, W.; Mei, Yan, Jin, Z. Tetrahedron Lett. 2004, 45, 8169.

An Improved Procedure for the Oxidative Cleavage of Olefins by OsO4-NaIO4, Hua, Z.; Yu, W.; Jin, Z. Org. Lett. 2004, 6, 3217.

Total Syntheses of the Highly Potent anti-HIV Natural Product Daurichromenic Acid and its Two  Novel Chromene Derivatives, Rhododaurichromanic Acids A and B, Kang, Y.; Mei, Y.; Du, Y.; Jin, Z. Org. Lett. 2003, 5, 4481.

Total Synthesis of An Antitumor Natural Product OSW-1, Yu, W.; Jin, Z. J. Am. Chem. Soc. 2002, 124, 6576.

Negishi Coupling between a-Alkyl(aryl)thio Vinyl Zinc Chloride and α-Bromo Vinyl Ether: a Convergent Synthesis of 2-Alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes, Su, M.; Kang, Y; Yu, W.; Hua, Z. Jin, Z. Org. Lett. 2002, 4, 691.

A Highly Stereoselective Synthesis of a-Halo Vinyl Sulfides and Their Applications in Organic Synthesis, Su, M.; Yu, W.; Jin, Z. Tetrahedron Lett. 2001, 42, 3771.

Synthetic Studies of Antitumor Marine Natural Products Superstolides A and B. Construction of C20-C26 Fragment of Superstolide A, Yu, W.; Zhang, Y.; Jin. Z. Org. Lett. 2001, 3, 1447.

A New Strategy for the Stereoselective Introduction of Steroid Side Chain via α-Alkoxy Vinyl Cuprates: Total Synthesis of a Highly Potent Antitumor Natural Product OSW-1, Yu, W.; Jin, Z. J. Am. Chem. Soc. 2001, 123, 3369.

A Facile Generation of Enolates from Silyl Enol Ethers by Potassium Ethoxide, Yu, W.; Jin, Z. Tetrahedron Lett. 2001, 42, 369.

A Facile Stereospecific Synthesis of α-Halo Vinyl Ethers and Their Applications in Organic Synthesis, Yu, W.; Jin, Z. J. Am. Chem. Soc. 2000, 122, 9840.

A Facile Chemoselective Deprotection of p-Methoxybenzyl Group, Yu, W.; Su, M.; Gao, X.; Yang, Z.; Jin, Z. Tetrahedron Lett. 2000, 41, 4015.

A Highly Selective Synthesis of (Z)-α,β-Unsaturated Ketones, Yu; W.; Su; M.; Jin, Z. Tetrahedron Lett. 1999, 40, 6725.

From The Scripps Research Institute

Total Synthesis of Everninomicin 13,384-1 - Part 4: Explorations of Methodology; Stereocontrolled Synthesis of 1,1'-Disaccharides, 1,2-Seleno Migrations in Carbohydrates, and Solution- and Solid-phase Synthesis of 2-Deoxy Glycosides and Orthoesters, Nicolaou, K. C.; Fylaktakidou, K. C.; Mitchell, H. J.; van Delft, F. L.; Rodriguez, R. M.; Conley, S. R.; Jin, Z. Chem. Eur. J. 2000, 6, 3166.

New Synthetic Technology for the Stereocontrolled Construction of 1,1'-Disaccharides and 1,1':1",2'-Trisaccharides, Synthesis of the FG Ring System of Everninomicin 13,384-1, Nicolaou, K. C.; van Delft, F. L.; Conley, S. R.; Mitchell, H. J.; Jin, Z.; Rodriguez, R. M. J. Am. Chem. Soc. 1997, 119, 9057.

From Purdue University
Palladium-Mediated Aminospirocyclization of Tertiary Allylic Sulfones: Stereospecific Construction of the Azabicyclic Ring System of Cephalotaxine, Jin, Z.; Fuchs, P. L. Tetrahedron Lett. 1996, 37, 5253.

Use of Phosphazene Base and Phase-Transfer Conditions for Regiospecific Alkylative Isomerization of Vinyl Sulfones Capable of Undergoing β-Elimination Reactions, Jin, Z.; Fuchs, P. L. Tetrahedron Lett. 1996, 37, 5249.

Phosphazene Base P2-Et Mediated Isomerization of Vinyl Sulfones to Allyl Sulfones, Jin, Z.; Kim, S. H.; Fuchs, P. L. Tetrahedron Lett. 1996, 37, 5247.

Synthesis of b-Substituted Cyclopentenones via Carbon Alkylation of Metalated γ-Methoxy-cyclopentenyl Phenylsulfonyl Anion, Kim, S. H.; Jin, Z.; Fuchs, P. L. Tetrahedron  Lett. 1995, 36, 4537.

Conversion of Vinylsulfones to Regiospecifically Functionalized Trisubstituted Olefins, Kim, S. H.; Jin, Z.;  Ma, S.; Fuchs, P. L. Tetrahedron Lett. 1995, 36, 4013.

Addition of γ-Methoxy Allylsulfonyl Anions to Cyclopentenyl Phenyl Sulfones. A Facile Synthesis of β-Cyclopentenyl-Substituted Dienones and Trienones, Jin, Z.; Fuchs, P. L. J. Am. Chem. Soc. 1995, 117, 3022.

New Synthetic Methods Exploiting Vinyl Sulfones Discovered During the Synthesis of a Natural Product, Jin, Z.; Vandort, P. C.; Fuchs, P. L. Phosphorus, Sulfur, and Silicon  1994, 95, 1.

A Highly Efficient Synthesis of β-Substituted 6 and 7-Membered Ring Enones via Carbon Alkylation of g-Methoxy Allylsulfonyl Anions, Jin, Z.; Fuchs, P. L. J. Am. Chem. Soc. 1994, 116, 5995.

Regiospecific Silver [I] Promoted, Palladium [0]-Catalyzed Intramolecular Addition of Aryl Iodides to Vinyl Sulfones, Jin, Z.; Fuchs, P. L. Tetrahedron Lett. 1993, 34, 5205.

Patent Filed
Total synthesis of OSW-1, Zhendong Jin, Wensheng Yu, Provisional Patent Application No.60/310,709.
Total Synthesis of the Highly Potent anti-HIV Natural Product Daurichromenic Acid along with Its Two Chromane Derivatives, Rhododaurichromanic Acids A and B, Ying Kang, Yan Mei, Zhendong Jin.
The Use of Orsaponin [3ß,16ß,17α-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxy-benzoyl-ß-D-xylopyranosyl)-(13)-(2-O-acetyl-α-L-arabinopyranoside)] and Its Derivatives for Cancer Therapeutics, Peng Huang, Michael J. Keating, Zhendong Jin.

College of Pharmacy
115 S. Grand Avenue Iowa City,
Iowa 52240
(319) 335-8794

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