Doorn Research Presentation
Doorn Research Group |
| Professional
Experience |
2004 – present. Assistant Professor, Division
of Medicinal and Natural Products Chemistry, College of Pharmacy,
University of Iowa, Iowa City, IA. |
2001 – 2004. Postdoctoral Fellow (NIH Traineeship
2001-2002; NRSA Fellowship 2002-2004), Dept. of Pharmaceutical Sciences,
School of Pharmacy, University of Colorado Health Sciences Center,
Denver, CO. |
1996 – 2001. Graduate Student (NIH Traineeship 1998-2001),
Toxicology Program, School of Public Health, University of Michigan,
Ann Arbor, MI. |
1997. Summer Internship/Professional, Dept. of Drug Delivery
Research and Development, Pharmacia and Upjohn Corporation, Kalamazoo,
MI. |
| Representative
Publications (2003 - Present) |
Rees, J.N., Florang, V.F., Anderson, D.G., and Doorn, J.A. (2007) Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate. Chem. Res. Toxicol. [accepted] |
Stewart, B.J., Doorn, J.A., and Petersen, D.R. (2007) Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization. Chem. Res. Toxicol. 20, 1111-1119 |
| Florang, V.F., Rees, J.R., Brogden, N.K., Anderson, D.G., Hurley,
T.D., and Doorn, J.A. (2007) Inhibition of the oxidative metabolism
of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine
metabolism, by 4-hydroxy-2-nonenal. Neurotoxicology. "28, 76-82." |
| Sampey, B.P., Carbone, D.L., Doorn, J.A., and Petersen, D.R. (2007)
4-Hydroxynonenal adduction and modulation of hepatocellular Erk 1/2
mitogen-activated protein kinase. Mol. Pharmacol. "71, 871-883." |
Rees, J.N., Florang, V.R., and Doorn, J.A. (2007) Inhibition of 3,4-dihydroxyphenylacetaldehyde metabolism leads to protein modification. The Toxicologist. 96 (1), 213. |
Anderson, D.G., Florang, V.R., and Doorn, J.A. (2007) Reactivity of dopamine oxidation products toward proteins. The Toxicologist. 96 (1), 214. |
| Florang, V.F., Rees, J.R., Brogden, N.K., Anderson, D.G., Hurley, T.D., and Doorn, J.A. (2007) Inhibition of mitochondrial aldehyde dehydrogenase-mediated oxidation of 3,4-dihydroxyphenylacetaldehyde. In Enzymology and Molecular Biology of Carbonyl Metabolism 13. (Weiner, E., Maser, E., Lindahl, R. and Plapp, B., Eds.) pp. 33-39, Purdue University Press, West Lafayette, Indiana |
| Doorn, J.A., Hurley, T.D., and Petersen, D.R. (2006) Inhibition
of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal
and 4-oxonon-2-enal. Chem. Res. Toxicol. 19,
102-110. |
| Carbone, D.L., Doorn, J.A., Kiebler, Z., and Petersen, D.R. (2005)
Cysteine modification by lipid peroxidation products inhibits protein
disulfide isomerase. Chem. Res. Toxicol. "18, 1324-1331." |
Carbone, D.L., Doorn, J.A., Kiebler, Z., Ickes, B.R., and Petersen,
D.R. (2005) Modification of Hsp90 by lipid peroxidation products
in a rat model of chronic alcoholic liver disease. J. Pharmacol.
Exp. Ther. "315, 8-15." |
Doorn, J.A., Maser, E., Blum, A., Claffey, D.J., and Petersen,
D.R. (2004) Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal.
Biochemistry 43, 13106-13114. |
Carbone, D.L., Doorn, J.A., Kiebler, Z., Sampey, B.P., and Petersen,
D.R. (2004) Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal.
Chem. Res. Toxicol. "17, 1459-1467." |
Carbone, D.L., Doorn, J.A., and Petersen, D.R. (2004) 4-Hydroxynonenal
regulates 26S proteasomal degradation of alcohol dehydrogenase.
Free Rad. Biol. Med. "37, 1430-1439." |
Petersen, D.R. and Doorn, J.A. (2004) Reactions of 4-hydroxynonenal
with proteins and cellular targets. Free Rad. Biol. Med.
37, 937-945. [Invited Review] |
Doorn, J.A., Srivastava, S., and Petersen, D.R. (2003). Aldose
reductase catalyzes reduction of the lipid peroxidation product
4-oxonon-2-enal. Chem Res. Toxicol. 16, 1418-1423. |
Doorn, J.A., Thompson, C.M., Christner, R.B., and Richardson,
R.J. (2003). Stereoselective inactivation of Torpedocalifornica
acetylcholinesterase by isomalathion: inhibitory reactions with
(1R)- and (1S)-isomers proceed by different
mechanisms. Chem. Res. Toxicol. 16, 958-965. |
| Awards/Honors |
| Class of 2010 Teacher of the Year, University of Iowa College of Pharmacy (2007). |
Transition to Independent Position Award (K22), National
Institute of Environmental Health Sciences (National Institutes
of Health), 2004-2007. |
First Place, Postdoctoral Presentation, Dept. of
Pharm. Sci. Annual Retreat, UCHSC, June 2003. |
Society of Toxicology 2003 Best Paper of the Year
Award, Paper: Doorn et al., (2002) Toxicol. Appl. Pharmacol.
176 , 73-80. Society of Toxicology Annual Meeting, Salt Lake City,
UT, March 2003. |
National Research Service Award, National Institute
of Environmental Health Sciences (National Institutes of Health),
2002-2004. |
| First Place in Graduate Student Poster Competition,
University of Michigan Annual Toxicology Symposium, Ann Arbor, MI,
April 2001. |
| Designed Artwork Featured on Front Cover of Chemical
Research in Toxicology, December 2000. Paper: Doorn et al.,
(2000) Chem.Res. Toxicol. 13, 1313-1320. |
First Place in Neurotoxicology Specialty Section
Poster Competition Society of Toxicology Annual Meeting, Philadelphia,
PA, March 2000. |
| Afilliations |
2006 – Present. Member, Human Toxicology Training Program, University of Iowa. |
2006 – Present. Member, Biosciences Training Program, University of Iowa. |
2005 – Present. Associate Member, Center for Environmental Health Sciences Research Center, Oxidative Stress and Metabolism Core, University of Iowa. |
| 2004 – Present. Member, Center for Biocatalysis and Bioprocessing, University of Iowa. |
|
