| |
 Daryl
J Murry , Pharm.D.
Associate Professor
S418 Phar
Iowa City, IA 52242
319-335-8157
E-mail: daryl-murry@uiowa.edu
| EDUCATION |
|
Pharmacokinetic Fellowship, St. Jude
Children's Research Hospital, Memphis, Tennessee, 1991-1994. |
|
Doctor of Pharmacy, University
of Iowa, Iowa City, Iowa, 1989-1991. |
|
ASHP Accredited Residency, University
of Iowa Hospitals and Clinics, Iowa City, Iowa, 1987-1988. |
|
Bachelor of Science, Pharmacy,
University of Iowa, Iowa City, Iowa, 1983 -1987. |
| Professional
Experience |
|
Member,
Holden Comprehensive Cancer Center, University
of Iowa, Iowa City, Iowa, 2003–present. |
|
Associate
Professor, Clinical and Administrative Pharmacy, University
of Iowa, Iowa City, Iowa, 2003–present. |
|
Associate
Professor, Department of Pharmacy Practice, Purdue
University, West Lafayette, Indiana, 2001–2003. |
|
Adjunct
Assistant Professor, Department of Industrial and Physical
Pharmacy, Purdue
University, West Lafayette, Indiana, 2000–2001. |
|
Assistant
Professor, Department of Pharmacy Practice, Purdue
University, Indianapolis, Indiana, 1998–2001. |
|
Adjunct
Assistant Professor, Department of Medicine, Indiana
University, Indianapolis, Indiana, 1998–2003. |
|
Assistant
Professor, Department of Pediatrics, Baylor College
of Medicine, Houston, Texas, 1994-1998. |
|
Co-Director,
Clinical Pharmacology Group, Baylor
College of Medicine and Texas Children’s Cancer Center, Houston, Texas, 1994-1998. |
|
Instructor,
Department of Clinical Pharmacy, University of Tennessee,
Memphis, Tennessee, 1991-1994. |
|
Clinical
Pharmacist, Pharmacy Department, University of Iowa
Hospitals and Clinics, Iowa City, Iowa 1988-1991. |
| Honors and Awards
|
|
Hoechst-Rousel Excellence
in Clinical Pharmacy, 1991. |
|
Upjohn
Research Award for Iowa Pharmacists, 1989. |
|
| Organizational
Memberships |
|
Recreation
Services Committee 2004-present. |
|
Graduate
Review Committee, 2004. |
|
CALGB
PET Committee, 2003-present. |
|
Curriculum
Committee, University of Iowa College of Pharmacy, 2003-present. |
|
Holden Cancer Center’s Protocol
Review and Monitoring Committee, 2003-present.
|
|
Teaching
Assistant Task Force, University of Iowa College of Pharmacy, 2003-2004. |
|
Ph.D. Task Force, University
of Iowa College of Pharmacy, 2003-2004. |
|
Promotional
Committee, University of Iowa College of Pharmacy, 2003-present. |
|
Anesthesiologist
Search Committee, Department of Veterinary Clinical Sciences, 2001. |
|
Grievance
Committee, Purdue University, 1999-2001. |
|
Jenkins-Knevel
Selection Committee, Purdue University,1999-2001. |
|
PRF
Grant Review Committee, Department of Pharmacy Practice, 1999-2000. |
|
Search
Committee, Walther Cancer Center, Purdue University, 1999-2000. |
|
Sub-Committee
on Graduate Applicant Review and Recruitment, Department
of Pharmacy Practice, 1999-2000. |
|
Graduate
Committee, Purdue University, Department of Pharmacy
Practice, 1999-2001. |
|
American College of Clinical Pharmacy |
|
American Society for Clinical
Oncology |
|
American Society for Clinical
Pharmacology and Therapeutics |
|
CALGB |
| Select Scholarly
Activities |
|
Sweeney CJ, Takimoto CH, Latz JE, Baker SD, Murry DJ, Krull JH, Fife K, Battiato L, Cleverly A, Chaudhary AK, Chaudhuri T, Sandler A, Mita AC, Rowinsky EK.Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or Ibuprofen in patients with advanced cancer. Clin Cancer Res. 2006 Jan 15;12(2):536-42. |
|
Schmidt MS, Huang R, Classon RJ, Murry DJ. Determination of vincristine in infant plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. J Pharm Biomed Anal. 2006 May 3;41(2):540-3. |
|
Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR. Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem Pharmacol. 2006 Jun 14;71(12):1695-704. |
|
Miller AA, Al Omari A, Murry DJ, Case D. Phase I and pharmacologic study of sequential topotecan-carboplatin-etoposide in patients with extensive stage small cell lung cancer. Lung Cancer. 2006 Dec;54(3):379-85. |
|
Naik
H, Murry DJ, Kirsch LE, Fleckenstein L. Development
and validation of a high-performance liquid chromatography-mass
spectroscopy assay for determination of artesunate
and dihydroartemisinin in human plasma. J Chromatogr
B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):233-42. |
|
Schmidt
MS, Prisinzano TE, Tidgewell K, Harding W, Butelman
ER, Kreek MJ, Murry DJ. Determination of Salvinorin
A in body fluids by high performance liquid chromatography-atmospheric
pressure chemical ionization. J Chromatogr B Analyt
Technol Biomed Life Sci. 2005 Apr 25;818(2):221-5. |
|
Quinney
SK, Sanghani SP, Davis WI, Hurley TD, Sun Z, Murry
DJ, Bosron WF. Hydrolysis of capecitabine to
5'-deoxy-5-fluorocytidine by human carboxylesterases
and inhibition by loperamide. J Pharmacol Exp Ther.
2005 Jun;313(3):1011-6. |
|
Sweeney
CJ, Mehrotra S, Sadaria MR, Kumar S, Shortle NH,
Roman Y, Sheridan C, Campbell RA, Murry DJ, Badve
S, Nakshatri H. The sesquiterpene lactone parthenolide
in combination with docetaxel reduces metastasis
and improves survival in a xenograft model of breast
cancer. Mol Cancer Ther. 2005 Jun;4(6):1004-12. |
|
Tidgewell, W.W. Harding, M.S. Schmidt, K.G. Holden, Murry DJ, and T.E. Prisinzano. A Facile Method
for the Preparation of Deuterium Labeled Salvinorin
A: Synthesis of [2,2,2-2H3]-Salvinorin A. Bioorganic
and Medicinal Chem. Lett., 14 (2004) 5099. |
|
EA Curry, Murry DJ,, C Yoder, K Fife, V Armstrong,
H Nakshatri M O’Connell CJ Sweeney. Phase
I dose escalation trial of feverfew with standardized
doses of parthenolide in patients with cancer. Investigational
New Drugs 22: 299-305, 2004. |
|
KD
Miller, SE Soule, TG Haney, P Guiney, Murry DJ,, L Lenaz,
SL Sun, GW Sledge. A
Phase II study of 9-nitro-camptothecin in patients with
previously treated metastatic breast cancer. Investigational
New Drugs 22: 69-73, 2004. |
|
MR Hemm, SD Rider, J Ogas, Murry DJ,, C Chapple. Light
induces phenylpropanoid metabolism in Arabidopsis
roots. The Plant Journal 38: 765-778, 2004. |
|
AK Fukunaga, S Marsh, Murry DJ,, TD Hurley
HL Mcleod. Identification and analysis of single-nucleotide
polymorphisms in the gemcitabine pharmacologic pathway. The
Pharmacogenomics Journal 4(5):307-14, 2004. |
|
Z Sun, Murry DJ,, SP Sanghani WI Davis NY Kedishvili,
Q Zou, TD Hurley, WF Bosron. Methylphenidate
is stereoselectively hydrolyzed by human carboxylesterase
CES1A1. J Pharmacol Exp Ther. 310(2) 469-76,
2004. |
|
Sanghani SP, Quinney SK, Fredenburg TB, Davis WI,
Murry DJ,, Bosron WF. Hydrolysis of irinotecan
and its oxidative metabolites, by human carboxylesterases
CES1A1, CES2, and a newly expressed carboxylesterase
isoenzyme, CES3. Drug Metabolism and Disposition
2004, 32:505-511. |
|
Boria PA, Murry DJ,, Bennett P, Glickman NW, Snyder
PW, Merkel BL, Schlittler D, Mutsaers AJ, Thomas
R, Bonney P, Knapp DW. Phase I/II clinical trial
of cisplatin/piroxicam in canine oral cancer. J Amer
Vet Med Assoc 2004, 224:1-7. |
|
Sanghani S.P., Quinney S.K., Fredenburg T.B., Sun
Z, Davis, W.I., Murry DJ, Cummings, O.W., Seitz,
D.E., Bosron, W.F. Carboxylesterases expressed
in human colon tumor tissue and their role in CPT-11
hydrolysis. Cancer Research 2003 9:4983-4991. |
|
Thompson, P., Balis, F., Serabe, B.M., Berg, S.,
Adamson, P., Klenke, R., Aiken, A., Packer, R., Murry DJ, Jakacki, R., Blaney S.M. Pharmacokinetics
of Phenylacetate administered as a 30 minute infusion
in children with refractory cancer. Cancer Chemother
Pharmacol 2003;52:417-423. |
|
de Wildt S.N., Kearns, G.L., Hop W.C.J.,Murry DJ, Abdel-Rahman S.M., van den Anker J.N. Pharmacokinetics
and metabolism of oral midazolam in preterm infants.
Br J Clin Pharmacol 2002;53:390-392. |
|
Murry DJ, Cherrick I, Salama V., Berg S., Bernstein
M., Kuttesch N., Blaney S.M. Influence of Phenytoin
on the Disposition of Irinotecan. Journal of Pediatric
Hematology/Oncology 2002;24:130-133. |
|
de Wildt S.N., Kearns, G.L., Hop W.C.J., Murry DJ, Abdel-Rahman S.M., van den Anker J.N. Pharmacokinetics
and metabolism of intravenous midazolam in preterm
infants. Clinical Pharmacology and Therapeutics 2001;70:525-530. |
|
Goldstein, S.L., Murry DJ, May S., Aleksic A.,
Sowinski, K.M. Blaney S. Meropenem pharmacokinetics
in children and adolescents receiving hemodialysis.
Ped Neph 2001;16:1015-8 |
|
Liang, H., Scott, M.K., Murry DJ, Sowinski,
K.M. Determination of albumin and myoglobin
in dialysate and ultrafiltrate samples by high-performance
size exclusion chromatography. Journal
of Chromatography B, 754 (2001) 141-151. |
|
Murry DJ, Blaney, S.M. Clinical
pharmacology of encaspulated sustained-release cytarabine. Annals
of Pharmacotherapy, 2000;34:1173-1178. |
|
Fausel, C.L., Murry DJ, Hematologic malignancies. Pharmacotherapy
Self-Assessment Program, 3rd Edition, 2000. |
|
| Research interests |
|
Clinical Pharmacology
of Feverfew in Prostate Cancer. Role: Co-Investigator. The
study is designed to evaluate the influence of parthenolide
on NF-KB. Status: Open for enrollment. |
|
Influence
of Interferon on Taxol Metabolism. Role: Co-Investigator. The
study is designed to evaluate the influence of prolonged
interferon therapy on taxol metabolism. Status:
Open for enrollment. |
|
Folate Status, Purine and
Pyrimindine Metabolism in Children with Down Syndrome. Role:
Principal Investigator. This study will evaluate
toxicity to antifolate drugs experienced by Down syndrome
patients being treated for childhood cancer. Study
closed, data analysis ongoing. |
|
Folate metabolism in children
with Down syndrome. Role: Principal Investigator. This
study will evaluate folate metabolism in children with
and without Down syndrome. Study closed, data analysis
ongoing. |
|
A trial of irinotecan in
children with solid tumors. Role: Co-Investigator
responsible for the pharmacology studies in this phase
I trial. Study closed, data analysis ongoing. |
|
Evaluation of three methods
to determine glomerular filtration rate in children. Role:
Co-Investigator. The study is designed to assess
the agreement between three tests used to determine glomerular
filtration rate in children. Study closed, data analysis
ongoing. |
|
|
|
| |
|
|
| |
|
|
|
