| |
 Lawrence
Fleckenstein , Pharm.D.
Professor
S 427 PHAR
319-335-8804 Office
319-353-5646 Fax
433 Laboratory
Email: l-fleckenstein@uiowa.edu
| EDUCATION |
|
Doctor of Pharmacy, University
of California, School of Pharmacy, San Francisco, CA, 1972. |
|
Bachelor of Arts, Botany,
University of California, Berkeley, CA, 1968. |
| Professional
Experience |
|
Professor, Division of Clinical and Administrative
Pharmacy, College of Pharmacy, The University of Iowa,
Iowa City, IA, 1991-Present. |
|
Acting Chief, Department of Pharmacology,
Division of Experimental Therapeutics, Walter Reed Army Institute of Research (WRAIR), Washington,
DC, 1988-1991. |
|
Supervisory Pharmacologist, Department of
Pharmacology, WRAIR, Washington, DC, 1986-1988. |
|
Adjunct Associate Professor, Department
of Pharmacology (Primary), Associate Research Professor, Department of Medicine (Secondary),
Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD,
1982-1991. |
|
Assistant Professor, Department of Pharmacology,
USUHS, Bethesda, MD, 1980-1982. |
|
Research Pharmacologist, Department of Pharmacology,
WRAIR, Washington, DC, 1979-1986. |
|
Assistant Professor (Clinical), School of
Pharmacy,University of California, San Francisco, CA, 1975-1979. |
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Director, Drug Information Service, Alta
Bates Hospital, Berkeley, CA, 1975-1979. |
|
Instructor of Pharmacology and Toxicology,
Department of Pharmacology, School of Medicine and Dentistry, University of Rochester, Rochester,
NY, 1972-1975. |
| Honors
and Awards |
|
Elected AAAS Fellow, 1995. |
|
Outstanding Service
Medal, USUHS, 1991. |
|
Commander's Award for
Civilian Service, WRAIR, 1989. |
|
U.S. Army Research and
Development Award, 1989. |
|
Exceptional Performance
Awards, WRAIR, 1982-1990. |
|
Awarded the Bowl of
Hygeia for Outstanding Pharm.D. Student, Class of 1972,
University of California, San Francisco, 1972. |
|
Rho Chi Pharmaceutical
Honor Society, University of California,San Francisco, 1972. |
|
Department of Botany
Citation for Outstanding Undergraduate Student, University
of California, Berkeley, 1968. |
|
Phi Beta Kappa, University
of California, Berkeley, 1968. |
|
| Organizational
Memberships |
|
Chair-Elect, Clinical Sciences
Section, American Association of Pharmaceutical Scientists, 2006. |
|
Vice-Chair, Clinical Sciences
Section, American Association of Pharmaceutical Scientists, 2005. |
|
Member, Graduate Council, 2003-2005. |
|
Chair, Pyronaridine-Artesunate
Development Team, Medicines for Malaria Venture, Geneva, Switzerland, 2001-present. |
|
Chair, Pharmacy Dean Search
Committee, 1997-1998. |
|
Vice President for Research
Advisory Committee in the Biological Sciences, Member, 1996-97, 1998-99, 2001-2002. |
|
Member, Hardin Health Sciences
Library Advisory Committee, 1994-1995. |
|
Member, Vice President of Health
Sciences Search Committee, 1992-1993. |
|
Member, Macrofil Chemotherapy
Project Steering Committee, World Health Organization, Geneva, Switzerland, 1991-1994. |
|
American Society for Clinical
Pharmacology and Therapeutics Board of Directors, 1990-1991. |
|
Member, Onchocerciasis Chemotherapy
Project Steering Committee, World Health Organization, Geneva, Switzerland, 1989-1991. |
|
Membership Committee, American
Society for Clinical Pharmacology and Therapeutics 1989-1994. |
|
USP Expert Advisory Committee
for Parasitic and Tropical Diseases, 2000-2005. Publications Committee, American Society for Clinical
Pharmacology and Therapeutics 1988-present: Chairman, 1990-1992. |
|
National Committee for Antibiotic/Drug
Review Task Force, Joint Commission on Accreditation of Hospitals, Chicago, Illinois, 1984-1985. |
|
American Association for the
Advancement of Science |
|
American Association of Pharmaceutical
Scientists |
|
American College of Clinical
Pharmacy (Charter member) |
|
American Pharmaceutical Association |
|
American Society for Pharmacology
and Experimental Therapeutics |
|
American Society for Tropical
Medicine and Hygiene |
|
International Society for the
Study of Xenobiotics (Charter member) |
|
Iowa Pharmacists Association |
| Select
Scholarly Activities |
|
Naik H, Wei SY, Schmidt MS, Murry DJ, Fleckenstein L, Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for the Determination of Pyronaridine in Human Urine. J. Chromato. B. Biomedical Applications 853:80-87, 2007. |
|
Al-Azzam S, Fleckenstein L, Cheng C, Dzimianski MT, McCall JW. Comparison of the Pharmacokinetics of Moxidectin and Ivermectin after Oral Administration to Beagle Dogs. Biopharm. Drug Disp. 28:431-8, 2007. |
|
Naik H, Imming PY, Schmidt MS, Murry DJ, Fleckenstein L, Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for the Determination of Pyronaridine in Human Blood for Application to Clinical Pharmacokinetic Studies. J. Pharm. Biomed. Anal. 45 112-9, 2007. |
|
Kitzman D, Wei SY, Fleckenstein
L, Liquid Chromatographic Assay of Ivermectin in Human
Plasma for Application to Clinical Pharmacokinetic Studies.
J. Pharm. Biomed. Anal., 40:1013-20, 2006. |
|
Turner SA, Maclean JD, Fleckenstein
L, and Greenaway C, Parenteral administration of ivermectin
in a patient with disseminated strongyloidiasis, Amer.
J. Trop. Med. Hyg. 73:911-914, 2005. |
|
Marty FM, Lowry CM, Rodriguez M,
Milner DA, Pieciak WS, Sinh, A, Fleckenstein
L, Baden LR, Treatment of human disseminated strongyloidiasis
with a parenteral veterinary formulation of ivermectin.
Clin. Inf. Dis. 41:e5-8, 2005. |
|
Naik H, Murry DJ, Kirsch LE, Fleckenstein
L, Development and validation of a high-performance liquid
chromatography-mass spectroscopy assay for determination
of artesunate and dihydroartemisinin in human plasma.
J. Chromato. B. Biomedical Applications, 816:233-242,
2005. |
|
Kshirsagar NA, Gogtay NJ, Garg BS, Deshmukh
PR, Rajgor DD, Kadam VS, Kirodian BG, Ingole NS, Mehendale
AM, Fleckenstein L, Karbwang J, Lazdins-Helds JK, Safety,
tolerability, efficacy and plasma concentrations of diethylcarbamazine
and albendazole co-administration in a field study in
an area endemic for lymphatic filariasis in India. Transactions
of the Royal Society of Tropical Medicine & Hygiene.
98(4):205-217, 2004 Apr |
|
Cotreau MM, Warren S, Ryan JL, Fleckenstein
L, Vanapalli SR, Brown KR, Rock D, Chen CY, Schwertschlag
US, The antiparasitic moxidectin: Safety, tolerability,
and pharmacokinetics in humans. Journal of Clinical Pharmacology.
43(10):1108-1115, 2003 Oct. |
|
Shenoy RK, Suma TK, John A, Arun SR, Kumaraswami
V, Fleckenstein L, Na- Bangchang K, The pharmacokinetics,
safety and tolerability of the co-administration of diethylcarbamazine
and albendazole. Annals of Tropical Medicine & Parasitology.
96(6):603-614, 2002. |
|
Vanapalli SR, Hung YP, Fleckenstein
L, Dzimianski MT, McCall JW, Pharmacokinetics
and dose proportionality of oral moxidectin in beagle
dogs. Biopharm. Drug Dispos. 23:263-272, 2002. |
|
Kitzman D, Cheng KJ, Fleckenstein
L, HPLC assay for albendazole and metabolites in human
plasma for clinical pharmacokinetic studies. J. Pharm.
Biomed. Anal., 30:801-813, 2002. |
|
Chen Y, Fleckenstein L, Assay method
for the determination of moxidectin in plasma by high-performance
liquid chromatography for application to clinical pharmacokinetic
studies. J. Pharm. Biomed. Anal. 29:917-926, 2002. |
|
Miller JR, Fleckenstein L, Gas chromatographic
assay of diethylcarbamazine in human plama for aplication
to clinical pharmacokinetic studies. J. Pharm. Biomed.
Anal. 26:667-676, 2001. |
|
Chen Y, Fleckenstein L, Improved assay
method for the determination of pyronaridine in plasma
and whole blood by high-performance liquid chromatography
for application to clinical pharmacokinetic studies. J.
Chromato. B. Biomedical Applications 752:39-46, 2001. |
|
Theplertboon R, Fleckenstein L, Dzimianski MT, McCall JW, Pharmacokinetics of UMF-078,
a candidate antifilarial drug, in infected dogs. Amer.
J. Trop. Med. Hyg. 62:86-91, 2000. |
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