College of Pharmacy - University of Iowa

Dr. Mahfoud Assem, pharmD, PhD.

Assistant Professor
S421 College of Pharmacy
University of Iowa, Iowa City, IA 52242
(319) 335-8839

EDUCATION
	Ph.D, Biochemistry, Molecular and Cellular Biology, School of Medicine and Pharmacy, University of Burgundy, Dijon, France, 1995-2000.
	M.S., Pharmacokinetics and Pharmacology, School of Pharmacy, University of Nancy I, Nancy, France, 1994-1995.
	B.S., Biology and Medical Sciences, School of Medicine and Pharmacy, University of Burgundy, Dijon, France, 1990-1992.
	Pharm.D., School of Medicine and Pharmacy, University of Burgundy, Dijon, France, 1986-1994.
Professional Experience
	Assistant Professor, Pharmacogenomics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 2007-present.
	Staff Scientist, Pharmacogenetics/Pharmacogenomics, St. Judes Children's Research Hospital, Memphis, Tennessee, 2005-2006.
	Post Doctoral Research Associate, Pharmacogenetics/Pharmacogenomics, St Judes Children's Research Hospital, Memphis, Tennessee, 2000-2004.
	Genetic Diagnosis and Research in Colon Cancer Genetic Cytology-Pathology-Oncology, Anatomie Pathologique, University Hospital, Dijon, France, 1996-2000.
	Laboratory Residency, Molecular Biology and Genetics (Genetic Diagnosis), Molecular Genetic Laboratory, University Hospital, Dijon, France, 1991-1995.
Honors and Awards
	Approved by the National University Council of France (Ministry of National Education).
	Qualified in Pharmaceutical Sciences (Pharmacology, Biochemistry, Molecular and Cellular Biology).
Research and Scholarly Interest Areas
	Ph. D. Thesis, Evolution of the antioxidant and antiapototic systems during initiation and development of a post ischemic heart failure induced by left artery coronary occlusion in rats.
	Pharm. D. Thesis, Analysis of the antioxidant system during heart ischemia following an obsctruction induced by left artery coronary occlusion.
Organizational Memberships
	Member of the Cambridge Health Institue Association, 2003-Present.
	Associate Member of the American Association of Cancer Research, 2003-Present.
Select Scholarly Activities
	Finkelstein D, Lamba V, Assem M , Rengelshausen J, Yasuda K, Strom S, Schuetz EG. The ADME Transcriptome in Hispanic versus White donor livers: Evidence of a Globally Enhanced NR1I3 (CAR, Constitutive Androstane Receptor) Gene Signature in Hispanics. Xenobiotica, 2006, 36(10-11):989-1012.
	Zhou CC, Assem M , Watkins PB, Blumberg B, Schuetz EG, Thummel KE. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J. Clin. Invest. 2006, 116(6):1703-12.
	Masson D, Pais de Barros JP, Zak Z, Gautier T, Leguern N, Assem M , Shisholm JW, Paterniti JR jr, Lagrost L. Human apolipoprotein AI expression in cholesteryl ester transfer protein (CETP) transgenic rats leads to fewer amounts of apo CI in high density lipoproteins (HDL) and to magnification of CETP-mediated lipoprotein changes. J. Lipid. Res. 2006, 47(2):356-65.
	Masson D, Lagrost L, Athias A, Gambert P, Brimer-Cline C, Lan L, Schuetz JD, Schuetz EG, Assem M . Expression of the pregnane X receptor (PXR) in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein Profile. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2164-2169
	Lamba V, Yasuda K, Lamba JK, Assem M , Davila J, Strom S, Schuetz EG. PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol. Appl. Pharmacol. 2004, 199(3):251-65.
	Lamba JK, Lamba V, Yasuda K, Lin YS, Assem M , Thompson E, Strom S, Schuetz EG. Expression of CAR splice variants in human tissues and their functional consequences. J Pharmacol. Exp. Ther. 2004, 311(2):811-21
	Schuetz EG et al., PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5. Pharmacol. Rev. 2004, 56(2):159.
	Assem M , Schuetz EG, Leggas M, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans R, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J. Biol. Chem. 2004, 279(21):22250-7
	Ecarnot-Laubriet A, Assem M , Poirson-Bichat F, Moisant M, Bernard C, Lecour S, Solary E, Rochette L, Teyssier JR. Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload. Biochim. Biophys. Acta. 2002, 1586(3):233-42
	Schuetz EG, Storm S, Yasuda K, Lecureur V, Assem M , Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venktaramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450. J. Biol. Chem. 2001, 276(42): 39411-8
	Laubriet A, Fantini E, Assem M , Cordelet C, Teyssier JR, Athias P, Rochette L. Changes in HSP70 and P53 expression are related to the pattern of electromechanical alterations in rat cardiomyocytes during simulated ischemia. Mol. Cell. Biochem. 2001, 220(1-2):77-86
	Kuehl P, Zhang J, Lin Y, Lamba J, Assem M , Schuetz J, Watkins P, Daly A, Wrighton S, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Storm S, Thummel K, Boguski MS, Schuetz E. Sequence diversity in cyp3A promoters and characterization of the genetic basis of polymorphic cyp3A5 expression. Nature Genetics. 2001, 27:383-391
	Chapusot C, Assem M , Martin L, Chalabreysse L, Benhamiche AM, Lignier MA, Chauffert B, Teyssier JR, Faivre J, Piard F. Expression of p21 WAF1/CIP1 protein in colorectal cancers: study of its relation to p53 mutation and Ki67 antigen expression. Pathol. Biol. 2001, 49(2):115-23
	Ecarnot-Laubriet A, De Luca K, Vandroux D, Moisant M, Bernard C, Assem M , Rochette L, Teyssier JR. Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload. J. Mol. Cell. Cardiol. 2000, 32(12):2385-95
	Martin L, Assem M , Piard F. Are there several types of colorectal carcinomas? Correlations with genetic data. Eur. J. Cancer. Prev. 1999, 8 Suppl 1:S13-20
	Dobsak P, Courderot-Masuyer C, Zeller M, Vergely C, Laubriet A, Assem M , Eicher JC, Teyssier JR, Wolf JE, Rochette L. Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J. Cardiovasc. Pharmacol. 1999, 34(5):651-9
	Creuzot-Garcher C, Guerzider V, Assem M , Bron AM, Delannoy P, Bara J. Alteration of sialyl Lewis epitope expression in pterygium. Invest. Ophthalmol. Vis. Sci. 1999, 40(8):1631-6
	Justrabo E, Zanetta G, Martin L, Assem M , Mousson C, Maurice-Estepa L, Rifle G, Tanter Y. Irreversible glomerular lesions induced by crystal precipitation in a renal transplant after foscarnet therapy for cytomegalovirus infection. Histopathology. 1999, 34(4):365-9
	Lewden O, Garcher C, Assem M , Morales C, Rochette L, Bron AM. Changes of the inducible heat shock protein 70 mRNA level in rat retina after ischemia and reperfusion. Ophthalmic Res. 1998;30(5):291-4
	Piard F, Yaziji N, Jarry O, Assem M , Martin L, Bernard A, Jacquot JP, Justrabo E. Solitary plasmacytoma of the lung with light chain extracellular deposits: a case report and review of the literature. Histopathology. 1998, 32(4):356-61
	Assem M , Teyssier JR, Benderitter M, Terrand J, Laubriet A, Javouhey A, David M, Rochette L. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Am. J. Pathol. 1997, 151(2):549-55
	Garrido C, Mehlen P, Fromentin A, Hammann A, Assem M , Arrigo AP, Chauffert B. Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. The doxorubicin-protecting effect of Hsp27. Eur. J. Biochem. 1996, 237(3):653-9
	Benderitter M, Maingon P, Abadie C, Assem M , Maupoil V, Briot F, Horiot JC, Rochette L. Effect of in vivo heart irradiation on the development of antioxidant defenses and cardiac functions in the rat. Radiat. Res. 1995, 144(1):64-72
	Garrido C, Chauffert B, Pinard D, Tibaut F, Genne P, Assem M , Dimanche-Boitrel MT. Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line. Int. J. Cancer. 1995, 61(6):873-9
	Assem M , Bonvalot S, Beltramo JL, Garrido C, Dimanche-Boitrel MT, Genne P, Rebibou JM, Caillot D, Chauffert B. Deleterious effect of serum proteins on the amphotericin B-induced potentiation of cisplatin in human colon cancer cells. Br. J. Cancer. 1994, 70(4):631-5